Tuberculosis origin: The Neolithic scenario.
Identifieur interne : 000087 ( Main/Exploration ); précédent : 000086; suivant : 000088Tuberculosis origin: The Neolithic scenario.
Auteurs : Israel Hershkovitz [Israël] ; Helen D. Donoghue [Royaume-Uni] ; David E. Minnikin [Royaume-Uni] ; Hila May [Israël] ; Oona Y-C Lee [Royaume-Uni] ; Michal Feldman [Israël] ; Ehud Galili [Israël] ; Mark Spigelman [Israël] ; Bruce M. Rothschild (médecin) [États-Unis] ; Gila Kahila Bar-Gal [Israël]Source :
- Tuberculosis (Edinburgh, Scotland) [ 1873-281X ] ; 2015.
English descriptors
- KwdEn :
- Adult, Animals, Biomarkers (analysis), Cattle, Chromatography, High Pressure Liquid, DNA, Bacterial (analysis), DNA, Bacterial (genetics), Female, History, Ancient, Humans, Infant, Lipids (analysis), Male, Mycobacterium tuberculosis (genetics), Mycolic Acids (analysis), Paleopathology (methods), Tuberculosis, Osteoarticular (genetics), Tuberculosis, Osteoarticular (history), Tuberculosis, Osteoarticular (pathology).
- MESH :
- chemical , analysis : Biomarkers, DNA, Bacterial, Lipids, Mycolic Acids.
- chemical , genetics : DNA, Bacterial.
- genetics : Mycobacterium tuberculosis, Tuberculosis, Osteoarticular.
- history : Tuberculosis, Osteoarticular.
- methods : Paleopathology.
- pathology : Tuberculosis, Osteoarticular.
- Adult, Animals, Cattle, Chromatography, High Pressure Liquid, Female, History, Ancient, Humans, Infant, Male.
Abstract
This paper follows the dramatic changes in scientific research during the last 20 years regarding the relationship between the Mycobacterium tuberculosis complex and its hosts - bovids and/or humans. Once the M. tuberculosis and Mycobacterium bovis genomes were sequenced, it became obvious that the old story of M. bovis evolving into the human pathogen should be reversed, as M. tuberculosis is more ancestral than M. bovis. Nevertheless, the timescale and geographical origin remained an enigma. In the current study human and cattle bone samples were examined for evidence of tuberculosis from the site of Atlit-Yam in the Eastern Mediterranean, dating from 9250 to 8160 (calibrated) years ago. Strict precautions were used to prevent contamination in the DNA analysis, and independent centers used to confirm authenticity of findings. DNA from five M. tuberculosis genetic loci was detected and had characteristics consistent with extant genetic lineages. High performance liquid chromatography was used as an independent method of verification and it directly detected mycolic acid lipid biomarkers, specific for the M. tuberculosis complex. These, together with pathological changes detected in some of the bones, confirm the presence of the disease in the Levantine populations during the Pre-pottery Neolithic C period, more than 8000 years ago.
DOI: 10.1016/j.tube.2015.02.021
PubMed: 25726364
Affiliations:
- Israël, Royaume-Uni, États-Unis
- Angleterre, Grand Londres, Kansas, Midlands de l'Ouest
- Birmingham, Lawrence (Kansas), Londres
- University College de Londres, Université de Birmingham, Université du Kansas
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Le document en format XML
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Electronic address: udi@israntique.org.il.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Israel Antiquities Authority, Jerusalem, Israel; Zinman Institute of Archaeology, Haifa University</wicri:regionArea><wicri:noRegion>Haifa University</wicri:noRegion></affiliation></author><author><name sortKey="Spigelman, Mark" sort="Spigelman, Mark" uniqKey="Spigelman M" first="Mark" last="Spigelman">Mark Spigelman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Kuvin Center for the Study of Infectious and Tropical Diseases, Hebrew University-Hadassah Medical School, Jerusalem, Israel. Electronic address: spigelman@btinternet.com.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Kuvin Center for the Study of Infectious and Tropical Diseases, Hebrew University-Hadassah Medical School, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Rothschild, Bruce M" sort="Rothschild, Bruce M" uniqKey="Rothschild B" first="Bruce M" last="Rothschild">Bruce M. Rothschild (médecin)</name><affiliation wicri:level="4"><nlm:affiliation>Carnegie Museum, Pittsburgh, PA 15702, USA; Biodiversity Institute and Department of Geology, University of Kansas, Lawrence, KS 66045, USA. 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Electronic address: gila.kahila@mail.huji.ac.il.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>The Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot</wicri:regionArea><wicri:noRegion>Rehovot</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25726364</idno><idno type="pmid">25726364</idno><idno type="doi">10.1016/j.tube.2015.02.021</idno><idno type="wicri:Area/PubMed/Corpus">000107</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000107</idno><idno type="wicri:Area/PubMed/Curation">000107</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000107</idno><idno type="wicri:Area/PubMed/Checkpoint">000107</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000107</idno><idno type="wicri:Area/Ncbi/Merge">000E21</idno><idno type="wicri:Area/Ncbi/Curation">000E21</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E21</idno><idno type="wicri:Area/Main/Merge">000088</idno><idno type="wicri:Area/Main/Curation">000087</idno><idno type="wicri:Area/Main/Exploration">000087</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Tuberculosis origin: The Neolithic scenario.</title><author><name sortKey="Hershkovitz, Israel" sort="Hershkovitz, Israel" uniqKey="Hershkovitz I" first="Israel" last="Hershkovitz">Israel Hershkovitz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address: anatom2@post.tau.ac.il.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv</wicri:regionArea><wicri:noRegion>Tel-Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Donoghue, Helen D" sort="Donoghue, Helen D" uniqKey="Donoghue H" first="Helen D" last="Donoghue">Helen D. Donoghue</name><affiliation wicri:level="4"><nlm:affiliation>Centres for Clinical Microbiology and the History of Medicine, University College London, London, UK. Electronic address: h.donoghue@ucl.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centres for Clinical Microbiology and the History of Medicine, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Minnikin, David E" sort="Minnikin, David E" uniqKey="Minnikin D" first="David E" last="Minnikin">David E. Minnikin</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK. Electronic address: d.e.minnikin@bham.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="May, Hila" sort="May, Hila" uniqKey="May H" first="Hila" last="May">Hila May</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address: hilamay@gmail.com.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv</wicri:regionArea><wicri:noRegion>Tel-Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Oona Y C" sort="Lee, Oona Y C" uniqKey="Lee O" first="Oona Y-C" last="Lee">Oona Y-C Lee</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK. Electronic address: leeoy@bham.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Feldman, Michal" sort="Feldman, Michal" uniqKey="Feldman M" first="Michal" last="Feldman">Michal Feldman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address: michalfe@gmail.com.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv</wicri:regionArea><wicri:noRegion>Tel-Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Galili, Ehud" sort="Galili, Ehud" uniqKey="Galili E" first="Ehud" last="Galili">Ehud Galili</name><affiliation wicri:level="1"><nlm:affiliation>Israel Antiquities Authority, Jerusalem, Israel; Zinman Institute of Archaeology, Haifa University, Israel. Electronic address: udi@israntique.org.il.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Israel Antiquities Authority, Jerusalem, Israel; Zinman Institute of Archaeology, Haifa University</wicri:regionArea><wicri:noRegion>Haifa University</wicri:noRegion></affiliation></author><author><name sortKey="Spigelman, Mark" sort="Spigelman, Mark" uniqKey="Spigelman M" first="Mark" last="Spigelman">Mark Spigelman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Kuvin Center for the Study of Infectious and Tropical Diseases, Hebrew University-Hadassah Medical School, Jerusalem, Israel. Electronic address: spigelman@btinternet.com.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Kuvin Center for the Study of Infectious and Tropical Diseases, Hebrew University-Hadassah Medical School, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Rothschild, Bruce M" sort="Rothschild, Bruce M" uniqKey="Rothschild B" first="Bruce M" last="Rothschild">Bruce M. Rothschild (médecin)</name><affiliation wicri:level="4"><nlm:affiliation>Carnegie Museum, Pittsburgh, PA 15702, USA; Biodiversity Institute and Department of Geology, University of Kansas, Lawrence, KS 66045, USA. Electronic address: bmr@ku.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Carnegie Museum, Pittsburgh, PA 15702, USA; Biodiversity Institute and Department of Geology, University of Kansas, Lawrence, KS 66045</wicri:regionArea><placeName><region type="state">Kansas</region><settlement type="city">Lawrence (Kansas)</settlement></placeName><orgName type="university">Université du Kansas</orgName><placeName><settlement type="city">Lawrence (Kansas)</settlement><region type="state">Kansas</region></placeName><orgName type="university" n="3">Université du Kansas</orgName></affiliation></author><author><name sortKey="Bar Gal, Gila Kahila" sort="Bar Gal, Gila Kahila" uniqKey="Bar Gal G" first="Gila Kahila" last="Bar-Gal">Gila Kahila Bar-Gal</name><affiliation wicri:level="1"><nlm:affiliation>The Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel. Electronic address: gila.kahila@mail.huji.ac.il.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>The Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot</wicri:regionArea><wicri:noRegion>Rehovot</wicri:noRegion></affiliation></author></analytic><series><title level="j">Tuberculosis (Edinburgh, Scotland)</title><idno type="eISSN">1873-281X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Animals</term><term>Biomarkers (analysis)</term><term>Cattle</term><term>Chromatography, High Pressure Liquid</term><term>DNA, Bacterial (analysis)</term><term>DNA, Bacterial (genetics)</term><term>Female</term><term>History, Ancient</term><term>Humans</term><term>Infant</term><term>Lipids (analysis)</term><term>Male</term><term>Mycobacterium tuberculosis (genetics)</term><term>Mycolic Acids (analysis)</term><term>Paleopathology (methods)</term><term>Tuberculosis, Osteoarticular (genetics)</term><term>Tuberculosis, Osteoarticular (history)</term><term>Tuberculosis, Osteoarticular (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Biomarkers</term><term>DNA, Bacterial</term><term>Lipids</term><term>Mycolic Acids</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA, Bacterial</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Mycobacterium tuberculosis</term><term>Tuberculosis, Osteoarticular</term></keywords><keywords scheme="MESH" qualifier="history" xml:lang="en"><term>Tuberculosis, Osteoarticular</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Paleopathology</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Tuberculosis, Osteoarticular</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Animals</term><term>Cattle</term><term>Chromatography, High Pressure Liquid</term><term>Female</term><term>History, Ancient</term><term>Humans</term><term>Infant</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This paper follows the dramatic changes in scientific research during the last 20 years regarding the relationship between the Mycobacterium tuberculosis complex and its hosts - bovids and/or humans. Once the M. tuberculosis and Mycobacterium bovis genomes were sequenced, it became obvious that the old story of M. bovis evolving into the human pathogen should be reversed, as M. tuberculosis is more ancestral than M. bovis. Nevertheless, the timescale and geographical origin remained an enigma. In the current study human and cattle bone samples were examined for evidence of tuberculosis from the site of Atlit-Yam in the Eastern Mediterranean, dating from 9250 to 8160 (calibrated) years ago. Strict precautions were used to prevent contamination in the DNA analysis, and independent centers used to confirm authenticity of findings. DNA from five M. tuberculosis genetic loci was detected and had characteristics consistent with extant genetic lineages. High performance liquid chromatography was used as an independent method of verification and it directly detected mycolic acid lipid biomarkers, specific for the M. tuberculosis complex. These, together with pathological changes detected in some of the bones, confirm the presence of the disease in the Levantine populations during the Pre-pottery Neolithic C period, more than 8000 years ago.</div></front></TEI><affiliations><list><country><li>Israël</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Kansas</li><li>Midlands de l'Ouest</li></region><settlement><li>Birmingham</li><li>Lawrence (Kansas)</li><li>Londres</li></settlement><orgName><li>University College de Londres</li><li>Université de Birmingham</li><li>Université du Kansas</li></orgName></list><tree><country name="Israël"><noRegion><name sortKey="Hershkovitz, Israel" sort="Hershkovitz, Israel" uniqKey="Hershkovitz I" first="Israel" last="Hershkovitz">Israel Hershkovitz</name></noRegion><name sortKey="Bar Gal, Gila Kahila" sort="Bar Gal, Gila Kahila" uniqKey="Bar Gal G" first="Gila Kahila" last="Bar-Gal">Gila Kahila Bar-Gal</name><name sortKey="Feldman, Michal" sort="Feldman, Michal" uniqKey="Feldman M" first="Michal" last="Feldman">Michal Feldman</name><name sortKey="Galili, Ehud" sort="Galili, Ehud" uniqKey="Galili E" first="Ehud" last="Galili">Ehud Galili</name><name sortKey="May, Hila" sort="May, Hila" uniqKey="May H" first="Hila" last="May">Hila May</name><name sortKey="Spigelman, Mark" sort="Spigelman, Mark" uniqKey="Spigelman M" first="Mark" last="Spigelman">Mark Spigelman</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Donoghue, Helen D" sort="Donoghue, Helen D" uniqKey="Donoghue H" first="Helen D" last="Donoghue">Helen D. Donoghue</name></region><name sortKey="Lee, Oona Y C" sort="Lee, Oona Y C" uniqKey="Lee O" first="Oona Y-C" last="Lee">Oona Y-C Lee</name><name sortKey="Minnikin, David E" sort="Minnikin, David E" uniqKey="Minnikin D" first="David E" last="Minnikin">David E. Minnikin</name></country><country name="États-Unis"><region name="Kansas"><name sortKey="Rothschild, Bruce M" sort="Rothschild, Bruce M" uniqKey="Rothschild B" first="Bruce M" last="Rothschild">Bruce M. Rothschild (médecin)</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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